New research suggests that patients who stop using popular slimming jabs like semaglutide or tirzepatide can put back on shed pounds far faster than those who stop traditional diet and exercise plans.
Research printed in a leading medical journal points out that while overweight individuals frequently drop a large proportion of their total mass while using the jabs, the weight returns at an estimated rate of 0.8 kg per month after stopping.
"People purchasing these medications should be informed of the risk of fast rebound weight gain when the medication concludes," warns researcher Dr. Susan Jebb.
This pace of recovery means a return to original weight within about a year and a half.
Analyzing Approaches
The research, which looked at 37 of studies involving thousands of participants, compared the outcomes of GLP-1 agonists with older methods.
Researchers note that people who lose weight through lifestyle changes alone usually have a more gradual weight regain—around 100 grams monthly—post-intervention.
The Reason for the Fast Rebound
Experts propose the way of the jabs explains the accelerated weight return.
GLP-1 drugs mimic a body's own chemical called GLP-1, which moderates feelings of fullness.
"Artificially providing GLP-1 concentrations far above than the body's typical production may cause the body to produce less of its own natural GLP-1, and could lessen responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Withdrawal of this medication leads to appetite is unsuppressed, making excessive eating a significant risk."
A Chronic Condition?
The NHS recommend the jabs for people with weight-linked medical conditions, alongside recommended lifestyle changes.
Many experts say that, given the high risk of weight regain, the treatment should be considered long-term.
This perspective is echoed by pharmaceutical companies, who note that the findings "emphasize the persistent character of obesity," akin to managing diseases like diabetes.
Patient Experiences
Individuals who have stopped the jabs explain a intense return of appetite.
"I experienced a trigger activating and you're instantly extremely hungry," described one woman.
The struggle is compounded if individuals have not established sustainable dietary or behavioural changes during therapy.
Widespread Adoption
Figures suggest that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with interest being substantial.
- Adoption is greater among females compared to males.
- The middle-aged age group shows the highest level of interest.
- Many obtain the medications through private prescriptions rather than the NHS.
In conclusion, experts emphasize that while these medications are powerful tools for shedding pounds, they are not a magic solution and lasting health benefits hinges on ongoing lifestyle support.
